Custom synthesis

From molecule
to production

Molecules designed on the compiler, engineered into a process, and scaled from the bench through pilot to production, for the markets we serve and the domains the compiler reaches.

6
Stages, one specification
Submit, compile, engineer, bench, pilot, produce
11
Markets, chemical and computational
Six chemical markets and five compiler domains
20 m³
Production campaigns
From gram-scale bench through 200 L pilot
Stages of a project

Our approach to custom synthesis

A custom molecule is a specification problem before it is a chemistry problem. We define the target and the performance it has to deliver, design and screen candidate structures computationally, and then carry the chosen structure through bench, pilot, and production against one specification and one set of analytical methods. What you qualify at the bench is what you receive at scale.

One specification

Agreed at the engineering stage and measured through bench, pilot, and production with the same analytical methods.

Designed before it is made

Candidate structures and routes are screened on the compiler, so the first bench batch is the right molecule.

One team, bench to plant

The chemists who design the route run the scale-up; nothing is handed off between stages.

01

Submit

Tell us the target

The project form on this page captures what a chemist needs to scope the work: the target chemistry or a reference product, the application and end use, the volume you expect, and the timeline. Every submission is reviewed by a chemist, who replies with questions, a feasibility view, and a proposed route.

  • A chemist reviews every submission
  • NDA available before technical detail is exchanged
02

Compile

Design on the compiler

The target is built on the RION compiler before anything is made: its predicted properties against the application, and candidate synthesis routes ranked by yield, selectivity, and raw-material availability. Structural variants are compared in silico, so the first bench batch is the right molecule.

  • Property predictions against your application
  • Ranked routes with raw-material sourcing
  • Structure alternatives with their trade-offs
03

Engineer

Route, raw materials, specification

The chosen route is engineered into a process: reagents and their sources, reaction conditions, work-up, and the analytical methods that will define the product. The specification is agreed with you here, so bench, pilot, and production are all measured against the same numbers.

  • Process package and raw-material plan
  • Agreed specification and analytical methods
  • TSCA status confirmed before scale-up
04

Bench

Gram to kilogram

Bench synthesis produces the first material for your evaluation, with full characterization against the agreed specification. Formulation and application testing happens here; iterations on chain length, counter-ion, carrier, or activity are quick.

  • Samples from 50 g to 5 kg
  • Certificate of analysis and FTIR reference
  • Iteration on structure and grade
05

Pilot

Kilogram to tote

Pilot batches establish the process at scale: heat and mass transfer, cycle time, impurity profile, and packaging. Pilot material supports your qualification, stability work, and any regulatory submission, under the same change control as our listed products.

  • 200 L batches; drums and totes
  • Process record and impurity profile
  • Material for qualification and registration
06

Produce

Tote to bulk

Production runs under the specification, analytical methods, and documentation established at pilot, with a certificate of analysis and an FTIR baseline on every lot. Supply agreements, exclusivity, and registration support are set up alongside.

  • Campaigns to 20 m³; totes, tank trucks, rail
  • Lot release against the agreed specification
  • Supply agreement, exclusivity, change control

Submit a project

A chemist scopes every submission. This is what happens after you send it.

01ReviewA RION chemist reads the brief and comes back with questions and a feasibility view.
02CompileThe target is screened on the compiler and a route is proposed.
03ProposalSpecification, sample plan, and a quotation for bench work.
·ConfidentialAn NDA is available before technical detail is exchanged.

ContactWho we should reply to

ProjectWhat you need made

Confidential.

Molecules for every market we serve

Custom synthesis runs across all eleven markets. In some it is a variant of a chemistry we already make: a chain cut, a counter-ion, a carrier, an activity. In others it is a molecule designed on the compiler for a property the market does not yet have on the shelf.

Oil & Gas

Corrosion inhibitors, foamers, and VES bases matched to a well’s brine, temperature, and gas

HI&I Cleaning

Cleaning surfactants and quats on a specified cut, counter-ion, and carrier

Water Treatment

Corrosion and deposit-control chemistries for a given water and dosing method

Personal Care

Mild surfactants and conditioning quats built to a formula and a claim

Agriculture

Adjuvants and emulsifiers for a specific active, crop, and spray water

Textiles & Leather

Softener, antistat, and finishing chemistries for a fiber or a hide

Catalysis

Catalyst precursors, ligands, and supported-metal chemistries designed on the compiler

Energy Storage

Electrolyte additives, ionic liquids, and binder chemistries for cells and capacitors

Semiconductor

Process chemicals and specialty reagents for wet processing and cleaning

Mining & Minerals

Collectors, frothers, and extractants for flotation and hydrometallurgy

Advanced Materials

Monomers, coupling agents, and functional additives for polymers and coatings